It is estimated that 5.3 million Americans have AD, with 10 to 13% of people older than 65 affected by the disease (Buckley & Schub, 2012)
Key words: Alzheimer's, late-onset Alzheimer's disease (AD) is the most common form of dementia and it is both progressive and incurable. Early-onset Alzheimer's disease is considered to be an onset of the symptoms before the age of 65 years of age (Canu, et al
Pathogenesis. The pathology of AD occurs in two phases: the earlier phase is characterized by the oligomers and the later phase is associated with the development of plaques (Chiarini, 2009)
(2011) suggest that late-onset Alzheimer's is a multifactorial disease that is based on the interaction between environmental factors and susceptible genes. Various environmental factors are known to induce acute and chronic systemic inflammation, which is associated with increased decline in cognitive function (Eikelenboom, et al
Other treatment targets include inflammation, tau pathology, neurogenesis, and oxidative stress (Woodward, 2012). The currently approved pharmacological treatments for AD include central cholinesterase inhibitors and mematine (Greenspan, 2012)
, 2011). The pathophysiology of AD is known to be influenced by the lower expression levels of sorting-protein receptor (sorLa) (Olgiati, et al
Alzheimer's has also been associated with decreased estrogen levels, cardiovascular disease, cardiovascular risk factors (such as obesity, hypertension, dyslipidemia, insulin resistance), depression, and lifestyle issues such as smoking, poor diet, lack of exercise, and alcohol consumption (Buckley & Schub, 2012). There is some evidence that memory functions are under strong genetic influence in older people whether or not they have AD, suggesting that memory function variability can only partly be attributed to the APOE genotype (Wilson, et al
These responses are not yet fully understood but are considered connected to the development of an allergen-specific immunological memory that deviates from the T-helper 2 (Chung & Adcock). The Genetic Factor Genetic factors are believed to assert strong influence over the development or triggering of an allergy (Barnes, 2003)
Pathophysiology of Asthma Asthma is a common respiratory disease believed to be influenced or determined by genetic and environmental factors, such as allergens and respiratory viruses (Chung & Adcock, 2001)
It is acute when it is severe and sudden (Hadjlladis, 2014), chronic when it develops for a long period of time, and fatal, when it leads to death. An acute first asthmatic attack can lead to chronic asthma if it is not treated (Hadjilladis)
As a result, more money should be allocated to programs that are linked to preventing behaviors that contribute to inflammation. This is primarily because higher patient education is associated with decreased peripheral inflammation and results in better health outcomes (Friedman & Herd, 2010, p
However, significant progress has been made to an extent that polio is no longer a public health threat in Europe. "Hygiene hypothesis" is relevant to public health in various ways including providing data on acquisition of immune disorders, demonstrating the link between high disease incidence and socio-economic level, and creating opportunities for therapeutic perspectives (Okada et al
Therefore, increased expenditures on programs relating to preventing behaviors resulting in inflammation helps save more lives because people more aware of their body with regards to inflammation. These programs help people to identify what enhances or lessens their bodies' inflammatory response (Pick, n