The high rate of comorbidity of major depressive disorder and substance abuse (particularly alcohol) is well documented (Kahler, Ramsey, Read & Brown 363). Likewise, there is a connection between major depressive disorder and the incidence of anger, aggression and domestic violence in the United States (Feldbau-Kohn, Heyman and O'Leary 347)
Irrespective of whether people know they have major depressive disorder or not, though, the consequences of the condition can be severe including suicide. The high rate of comorbidity of major depressive disorder and substance abuse (particularly alcohol) is well documented (Kahler, Ramsey, Read & Brown 363)
Stressful life events; and, 5. Social isolation (especially prevalent among the elderly) (Zieve and Merrill 1-2)
If depression is very severe, there may also be psychotic symptoms, such as hallucinations and delusions (Zieve and Merrill 3). Major depressive disorder can be successfully treated in many cases with pharmacological and clinical interventions (Pasto & Burack 240)